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KMID : 1033820000010010073
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Journal of Artificial Heart Research
2000 Volume.1 No. 1 p.73 ~ p.0
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A study on the physiological control of a moving actuator artificial heart using computer simulation
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Jo Yung-Ho
Min Byoung-Goo
Park Sung-Keun
Kim Soo-Jung
Chol Jae-Soon
Lee Ji-Hoon
Choi Min-Joo
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Abstract
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The study is to develop a computer simulation model for predicting the physiological parameters of the cardiovascular system of the end stage heart failure patients with an artificial heart - a moving actuator type artificial heart used for a bi-ventricular assist device: BVAD and is to propose an physiologically optimal control algorithm for the BVAD using the model. The artificial heart model consists of the several coupled nonlinear differential equations and calculates the values of the hemodynamic parameters at the systolic and diastolic stages of each ventricle. The simulation model was constructed by combining the artificial heart model and a proven circulatory physiology model (QCP2). Unknown variables in the model were determined by in vitro mock circulation measurements and the simulation model was validated with animal experiments. Simulation considered the usual posture and activity changes of the patient with the BVAD and was carried out for various control modes such as the fixed rate control (Fixed), the preload sensitive control (Preload), the heart rate synchronized control (HR synch). The simulated results were compared with the responses from a healthy man. When the patient changed his position from lying to standing, the HR synch mode showed the best responses among the others and the Fixed mode appeared the second best. For the patient running in a treadmill with 3mile/hr for 10 minutes, it was predicted that both the HR synch mode and the Preload mode showed good responses. In conclusion, it is proposed that, for the optimal physiological control of the moving actuator bi-ventricular assist device, the HR synch control is to be taken as a primary automatic control algorithm and the Preload and the Fixed controls as the supplementary control modes.
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KEYWORD
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computer simulation, bi-ventricular assist device, optimal physiological control
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